Although understanding of the pathogenesis and molecular biology of primary myelofibrosis
continues to improve, treatment options are limited, and several biological features remain
unexplained. With an appropriate clinical history, exam, laboratory evaluation, and bone
marrow biopsy, the diagnosis can often be established. Recent studies have better
characterized prognostic factors and driver mutations in myelofibrosis, facilitated by use of
next-generation sequencing. These advances have facilitated development of a …