The role of cytokines in the initiation and progression of myelofibrosis
HC Hasselbalch - Cytokine & growth factor reviews, 2013 - Elsevier
Myelofibrosis (MF) is a life-threatening blood cancer characterized by progressive bone
marrow fibrosis, splenomegaly, cytopenias, and debilitating constitutional symptoms.
Abnormal expression and activity of a number of proinflammatory cytokines are associated
with MF, in which immune dysregulation is pronounced as evidenced by dysregulation of
several immune and inflammation genes. The discovery of the Janus kinase 2 (JAK2) V617F
mutation has led to the development of a number of JAK1/2 inhibitors in the treatment of MF …
marrow fibrosis, splenomegaly, cytopenias, and debilitating constitutional symptoms.
Abnormal expression and activity of a number of proinflammatory cytokines are associated
with MF, in which immune dysregulation is pronounced as evidenced by dysregulation of
several immune and inflammation genes. The discovery of the Janus kinase 2 (JAK2) V617F
mutation has led to the development of a number of JAK1/2 inhibitors in the treatment of MF …