[PDF][PDF] Cellular differentiation and expression of matrix genes in type 1 neurofibromatosis.

J Peltonen, S Jaakkola, M Lebwohl, S Renvall… - Lab …, 1988 - researchgate.net
The cellular heterogeneity of cutaneous tumors from nine patients with type 1 (von
Recklinghausen's) neurofibromatosis was studied using several antigenic markers with
special reference to focal heterotopic differentiation and interindividual variation.
Furthermore, cells which actively express the genes for type I and III collagens and
fibronectin, the major components of the abundant extracellular matrix of neurofibromas,
were localized using in situ hybridizations. In eight of nine cases, the S-100 protein positive …