[HTML][HTML] New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells
L Padet, M Dieudé, A Karakeussian-Rimbaud… - American Journal of …, 2019 - Elsevier
Autoantibodies against perlecan/LG3 (anti-LG3) have been associated with increased risks
of delayed graft function, acute rejection, and reduced long-term survival. High titers of anti-
LG3 antibodies have been found in de novo renal transplants recipients in the absence of
allosensitizing or autoimmune conditions. Here, we seek to understand the pathways
controlling anti-LG3 production prior to transplantation. Mice immunized with recombinant
LG3 produce concomitantly IgM and IgG anti-LG3 antibodies suggesting a memory …
of delayed graft function, acute rejection, and reduced long-term survival. High titers of anti-
LG3 antibodies have been found in de novo renal transplants recipients in the absence of
allosensitizing or autoimmune conditions. Here, we seek to understand the pathways
controlling anti-LG3 production prior to transplantation. Mice immunized with recombinant
LG3 produce concomitantly IgM and IgG anti-LG3 antibodies suggesting a memory …