Humoral immunity in phenotypes of chronic lung allograft dysfunction: a broncho-alveolar lavage fluid analysis
E Vandermeulen, SE Verleden, H Bellon… - Transplant …, 2016 - Elsevier
Background Recently, antibody mediated rejection (AMR) has been associated with a
higher incidence of chronic lung allograft dysfunction (CLAD) and mortality after lung
transplantation (LTx). We investigated markers related to AMR and matrix remodeling in
CLAD, with special attention for its two phenotypes being bronchiolitis obliterans syndrome
(BOS) and restrictive CLAD (rCLAD). Methods Immunoglobulins (IgA, IgE, IgG 1–IgG 4, total
IgG and IgM) and complement (C4d and C1q) were quantified in lung lavage samples at the …
higher incidence of chronic lung allograft dysfunction (CLAD) and mortality after lung
transplantation (LTx). We investigated markers related to AMR and matrix remodeling in
CLAD, with special attention for its two phenotypes being bronchiolitis obliterans syndrome
(BOS) and restrictive CLAD (rCLAD). Methods Immunoglobulins (IgA, IgE, IgG 1–IgG 4, total
IgG and IgM) and complement (C4d and C1q) were quantified in lung lavage samples at the …