Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models
M Polasek, BC Fuchs, R Uppal, DT Schühle… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Liver biopsy, the current clinical gold standard for fibrosis
assessment, is invasive and has sampling errors, and is not optimal for screening,
monitoring, or clinical decision-making. Fibrosis is characterized by excessive accumulation
of extracellular matrix proteins including type I collagen. We hypothesize that molecular
magnetic resonance imaging (MRI) with a probe targeted to type I collagen could provide a
direct and non-invasive method of fibrosis assessment. METHODS: Liver fibrosis was …
assessment, is invasive and has sampling errors, and is not optimal for screening,
monitoring, or clinical decision-making. Fibrosis is characterized by excessive accumulation
of extracellular matrix proteins including type I collagen. We hypothesize that molecular
magnetic resonance imaging (MRI) with a probe targeted to type I collagen could provide a
direct and non-invasive method of fibrosis assessment. METHODS: Liver fibrosis was …