[HTML][HTML] Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in …
N Takahashi, T Kawada, T Yamamoto, T Goto… - Journal of Biological …, 2002 - ASBMB
The cAMP-response element-binding protein-binding protein (CBP) and p300 are common
coactivators for several transcriptional factors. It has been reported that both CBP and p300
are significant for the activation of peroxisome proliferator-activated receptor γ (PPARγ),
which is a crucial nuclear receptor in adipogenesis. However, it remains unclear whether
CBP and/or p300 is physiologically essential to the activation of PPARγ in adipocytes and
adipocyte differentiation. In this study, we investigated the physiological significance of …
coactivators for several transcriptional factors. It has been reported that both CBP and p300
are significant for the activation of peroxisome proliferator-activated receptor γ (PPARγ),
which is a crucial nuclear receptor in adipogenesis. However, it remains unclear whether
CBP and/or p300 is physiologically essential to the activation of PPARγ in adipocytes and
adipocyte differentiation. In this study, we investigated the physiological significance of …