Zinc-deficient diet aggravates ventilation-induced lung injury in rats
X Chen, J Bian, Y Ge - Journal of Biomedical Research, 2012 - Elsevier
We investigated the effects of zinc deficiency on acute lung injury (ALI) induced by
mechanical ventilation. Male Sprague-Dawley rats were fed with a zinc-deficient or zinc-
proficient diet for 4 weeks, and then received mechanical ventilation at normal frequency
and pressure for 30 min. Total protein, cell count, the number of poly-morphonuclear
neutrophil (PMN) in the bronchoalveolar lavage (BAL), and vascular endothelial growth
factor (VEGF) expression in the lung were determined. Activation of nuclear factor-κB (NF …
mechanical ventilation. Male Sprague-Dawley rats were fed with a zinc-deficient or zinc-
proficient diet for 4 weeks, and then received mechanical ventilation at normal frequency
and pressure for 30 min. Total protein, cell count, the number of poly-morphonuclear
neutrophil (PMN) in the bronchoalveolar lavage (BAL), and vascular endothelial growth
factor (VEGF) expression in the lung were determined. Activation of nuclear factor-κB (NF …