[HTML][HTML] Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway
Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging
and dietary restriction (which retards many age-related changes) on components of the
ubiquitin proteasome system (UPS) in muscle. The hindlimb muscles of aged (30 months
old) rats showed a marked loss of muscle mass and contained 2–3-fold higher levels of 26S
proteasomes than those of adult (4 months old) controls. 26S proteasomes purified from …
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging
and dietary restriction (which retards many age-related changes) on components of the
ubiquitin proteasome system (UPS) in muscle. The hindlimb muscles of aged (30 months
old) rats showed a marked loss of muscle mass and contained 2–3-fold higher levels of 26S
proteasomes than those of adult (4 months old) controls. 26S proteasomes purified from …
