ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology …
Z Razinia, M Baldassarre, G Cantelli… - Journal of Biological …, 2013 - jbc.org
Filamins are actin-binding and cross-linking proteins that organize the actin cytoskeleton
and anchor transmembrane proteins to the cytoskeleton and scaffold signaling pathways.
During hematopoietic cell differentiation, transient expression of ASB2α, the specificity
subunit of an E3-ubiquitin ligase complex, triggers acute proteasomal degradation of
filamins. This led to the proposal that ASB2α regulates hematopoietic cell differentiation by
modulating cell adhesion, spreading, and actin remodeling through targeted degradation of …
and anchor transmembrane proteins to the cytoskeleton and scaffold signaling pathways.
During hematopoietic cell differentiation, transient expression of ASB2α, the specificity
subunit of an E3-ubiquitin ligase complex, triggers acute proteasomal degradation of
filamins. This led to the proposal that ASB2α regulates hematopoietic cell differentiation by
modulating cell adhesion, spreading, and actin remodeling through targeted degradation of …