[HTML][HTML] Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦
The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory
protein Vpx in myeloid lineage cells. Mutations in the SAMHD1 gene cause Aicardi-
Goutières syndrome, a genetic disease that mimics congenital viral infection. To determine
the physiological function of the SAMHD1 protein, the SAMHD1 gene was cloned,
recombinant protein was produced, and the catalytic activity of the purified enzyme was
identified. We show that SAMHD1 contains a dGTP-regulated deoxynucleotide …
protein Vpx in myeloid lineage cells. Mutations in the SAMHD1 gene cause Aicardi-
Goutières syndrome, a genetic disease that mimics congenital viral infection. To determine
the physiological function of the SAMHD1 protein, the SAMHD1 gene was cloned,
recombinant protein was produced, and the catalytic activity of the purified enzyme was
identified. We show that SAMHD1 contains a dGTP-regulated deoxynucleotide …