[HTML][HTML] Association of esophageal candidiasis and squamous cell carcinoma

CE Delsing, CP Bleeker-Rovers… - Medical mycology case …, 2012 - Elsevier
CE Delsing, CP Bleeker-Rovers, FL Van De Veerdonk, J Tol, JWM Van der Meer…
Medical mycology case reports, 2012Elsevier
Chronic esophageal candidiasis is an infection that is mostly seen in immunocompromised
conditions, among which is chronic mucocutaneous candidiasis (CMC). Recently an
association between CMC and esophageal carcinoma has been reported. Here we present
two patients with chronic esophageal candidiasis who developed esophageal squamous
cell carcinoma and we discuss the etiologic role of Candida-induced nitrosamine
production, the loss of STAT1 function and impaired tumor surveillance and T-lymphocyte …
Abstract
Chronic esophageal candidiasis is an infection that is mostly seen in immunocompromised conditions, among which is chronic mucocutaneous candidiasis (CMC). Recently an association between CMC and esophageal carcinoma has been reported. Here we present two patients with chronic esophageal candidiasis who developed esophageal squamous cell carcinoma and we discuss the etiologic role of Candida-induced nitrosamine production, the loss of STAT1 function and impaired tumor surveillance and T-lymphocyte function in the development of esophageal carcinoma.
Elsevier