[PDF][PDF] PKCλ/ι loss induces metabolic reprogramming in liver cancer: hitting two birds with one stone?
P Ramadori, X Li, M Heikenwalder - Cancer cell, 2020 - cell.com
P Ramadori, X Li, M Heikenwalder
Cancer cell, 2020•cell.comIn this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in
hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular
metabolic reprogramming that induces two reciprocally sustainable processes, oxidative
phosphorylation and autophagy, which promote liver-tumor aggressiveness in an NRF2-
dependent manner.
hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular
metabolic reprogramming that induces two reciprocally sustainable processes, oxidative
phosphorylation and autophagy, which promote liver-tumor aggressiveness in an NRF2-
dependent manner.
In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote liver-tumor aggressiveness in an NRF2-dependent manner.
cell.com