[HTML][HTML] Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2

S Kühnle, U Kogel, S Glockzin, A Marquardt… - Journal of Biological …, 2011 - ASBMB
Deregulation of the ubiquitin-protein ligase E6AP contributes to the development of the
Angelman syndrome and to cervical carcinogenesis suggesting that the activity of E6AP
needs to be under tight control. However, how E6AP activity is regulated at the post-
translational level under non-pathologic conditions is poorly understood. In this study, we
report that the giant protein HERC2, which is like E6AP a member of the HECT family of
ubiquitin-protein ligases, binds to E6AP. The interaction is mediated by the RCC1-like …