Abstract Development of spontaneous seizures is the hallmark of human epilepsy. There is
a critical need for new epilepsy models in order to elucidate mechanisms responsible for
leading to the development of spontaneous seizures and for testing new anti-epileptic
compounds. Moreover, rodent models of epilepsy have clearly demonstrated that there are
two independent seizure systems in the brain: 1) the forebrain seizure network required for
the expression of clonic seizures mediated by forebrain neurocircuitry, and 2) the brainstem …