Late kidney allograft loss: what we know about it, and what we can do about it

AM Jevnikar, RB Mannon - … Journal of the American Society of …, 2008 - journals.lww.com
Despite dramatic improvements in immunosuppression, late graft loss after kidney
transplantation remains a common and difficult problem. Histologic evaluation may reveal
changes related to BK polyomavirus infection, hypertension, or calcineurin inhibitor toxicity,
which can help to guide therapy. The designation chronic allograft nephropathy should thus
be reserved for biopsies with tubular atrophy and interstitial fibrosis without an apparent
cause. Although the cause clearly includes both antigen-dependent and antigen …