Transcriptomes of major proximal tubule cell culture models

SJ Khundmiri, L Chen, ED Lederer… - Journal of the …, 2021 - journals.lww.com
Background Cultured cell lines are widely used for research in the physiology,
pathophysiology, toxicology, and pharmacology of the renal proximal tubule. The lines that
are most appropriate for a given use depend upon the genes expressed. New tools for
transcriptomic profiling using RNA sequencing (RNA-Seq) make it possible to catalog
expressed genes in each cell line. Methods Fourteen different proximal tubule cell lines,
representing six species, were grown on permeable supports under conditions specific for …