Noninvasive diagnosis and prognostication of acute cellular rejection in the kidney allograft
may help realize the full benefits of kidney transplantation. To investigate whether urine
metabolites predict kidney allograft status, we determined levels of 749 metabolites in 1516
urine samples from 241 kidney graft recipients enrolled in the prospective multicenter
Clinical Trials in Organ Transplantation-04 study. A metabolite signature of the ratio of 3-
sialyllactose to xanthosine in biopsy specimen-matched urine supernatants best …