Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation
Y Bei, T Hua-Huy, S Duong-Quy, VH Nguyen… - Pulmonary …, 2013 - Elsevier
Pulmonary hypertension (PH) associated with pulmonary fibrosis (PF) considerably worsens
prognosis of interstitial lung diseases (ILD). RhoA/Rho-kinases (ROCK) pathway is
implicated in high pulmonary vascular tone and pulmonary fibrosis but the effect of ROCK
inhibitors on PH associated with PF is not known. We therefore aimed to determine whether
long-term treatment with fasudil, a selective ROCK inhibitor, could attenuate PF and PH
induced by bleomycin in mice. Male C57BL/6 mice received a single dose of intratracheal …
prognosis of interstitial lung diseases (ILD). RhoA/Rho-kinases (ROCK) pathway is
implicated in high pulmonary vascular tone and pulmonary fibrosis but the effect of ROCK
inhibitors on PH associated with PF is not known. We therefore aimed to determine whether
long-term treatment with fasudil, a selective ROCK inhibitor, could attenuate PF and PH
induced by bleomycin in mice. Male C57BL/6 mice received a single dose of intratracheal …