[HTML][HTML] Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and …
T Mitamura, S Higashiyama, N Taniguchi… - Journal of Biological …, 1995 - ASBMB
The membrane anchored form of human heparin-binding epidermal growth factor-like
growth factor (HB-EGF) acts as the diphtheria toxin (DT) receptor. Transfection of human HB-
EGF cDNA into mouse LC cells, L cells stably expressing DRAP27, conferred sensitivity to
DT, but transfection of mouse HB-EGF cDNA did not. To define the essential regions of HB-
EGF that serve as the functional DT receptor, we examined the sensitivity to DT and DT
binding of cells expressing several human/mouse HB-EGF chimeras. It was found that DT …
growth factor (HB-EGF) acts as the diphtheria toxin (DT) receptor. Transfection of human HB-
EGF cDNA into mouse LC cells, L cells stably expressing DRAP27, conferred sensitivity to
DT, but transfection of mouse HB-EGF cDNA did not. To define the essential regions of HB-
EGF that serve as the functional DT receptor, we examined the sensitivity to DT and DT
binding of cells expressing several human/mouse HB-EGF chimeras. It was found that DT …