Amphiregulin aggravates glomerulonephritis via recruitment and activation of myeloid cells
S Melderis, J Hagenstein, MT Warkotsch… - Journal of the …, 2020 - journals.lww.com
Background Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin
(AREG) as an important mediator of inflammatory diseases. Both pro-and anti-inflammatory
functions have been described, but the role of AREG in GN remains unknown. Methods The
nephrotoxic nephritis model of GN was studied in AREG−/− mice after bone marrow
transplantation, and in mice with myeloid cell–specific EGFR deficiency. Therapeutic utility of
AREG neutralization was assessed. Furthermore, AREG's effects on renal cells and …
(AREG) as an important mediator of inflammatory diseases. Both pro-and anti-inflammatory
functions have been described, but the role of AREG in GN remains unknown. Methods The
nephrotoxic nephritis model of GN was studied in AREG−/− mice after bone marrow
transplantation, and in mice with myeloid cell–specific EGFR deficiency. Therapeutic utility of
AREG neutralization was assessed. Furthermore, AREG's effects on renal cells and …