A growing literature indicates that mitochondria are key participants in innate immune
pathways, functioning as both signaling platforms and contributing to effector responses. In
addition to regulating antiviral signaling and antibacterial immunity, mitochondria are also
important drivers of inflammation caused by sterile injury. Much research on mitochondrial
control of immunity now centers on understanding how mitochondrial constituents released
during cellular damage simulate the innate immune system. When mitochondrial integrity is …