[HTML][HTML] Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival
D Abreu, R Asada, JMP Revilla, Z Lavagnino… - Laboratory …, 2020 - Elsevier
Abstract Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor
whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and
apoptosis. The mechanisms guiding β-cell outcomes secondary to WFS1 function, however,
remain unclear. Here, we show that WFS1 preserves normal β-cell physiology by promoting
insulin biosynthesis and negatively regulating ER stress. Depletion of Wfs1 in vivo and in
vitro causes functional defects in glucose-stimulated insulin secretion and insulin content …
whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and
apoptosis. The mechanisms guiding β-cell outcomes secondary to WFS1 function, however,
remain unclear. Here, we show that WFS1 preserves normal β-cell physiology by promoting
insulin biosynthesis and negatively regulating ER stress. Depletion of Wfs1 in vivo and in
vitro causes functional defects in glucose-stimulated insulin secretion and insulin content …
