Contraction is crucial in maintaining the differentiated phenotype of myofibroblasts.
Contraction is an energy-dependent mechanism that relies on the production of ATP by
mitochondria and/or glycolysis. Although the role of mitochondrial biogenesis in the adaptive
responses of skeletal muscle to exercise is well appreciated, mechanisms governing
energetic adaptation of myofibroblasts are not well understood. Our study demonstrates
induction of mitochondrial biogenesis and aerobic glycolysis in response to the …