Role of type I interferons and innate immunity in systemic sclerosis: unbalanced activities on distinct cell types?
Recent results support a pathogenic role for IFN-I in skin fibrosis, and recent studies along
with others suggest a scenario whereby SSc skin damage results from too much IFN-I-
activity driving vasculopathy in combination with too little IFN-I-mediated epidermal integrity
and antifibrotic fibroblast phenotype.
with others suggest a scenario whereby SSc skin damage results from too much IFN-I-
activity driving vasculopathy in combination with too little IFN-I-mediated epidermal integrity
and antifibrotic fibroblast phenotype.
Summary
Recent results support a pathogenic role for IFN-I in skin fibrosis, and recent studies along with others suggest a scenario whereby SSc skin damage results from too much IFN-I-activity driving vasculopathy in combination with too little IFN-I-mediated epidermal integrity and antifibrotic fibroblast phenotype.
Lippincott Williams & Wilkins