Leukemia inhibitory factor induces DNA synthesis in Swiss mouse 3T3 cells independently of cyclin D1 expression through a mechanism involving MEK/ERK1/2 …
A Dekanty, M Sauane, B Cadenas, F Coluccio… - Journal of Biological …, 2006 - jbc.org
Leukemia inhibitory factor (LIF) and oncostatin M (OSM) induce DNA synthesis in Swiss 3T3
cells through common signaling mechanism (s), whereas other related cytokines such as
interleukin-6 and ciliary neurotrophic factor do not cause this response. Induction of DNA
replication by LIF or prostaglandin F 2α (PGF 2α) occurs, in part, through different signaling
events. LIF and OSM specifically trigger STAT1 cytoplasmic to nuclear translocation,
whereas PGF 2α fails to do so. However, LIF and PGF 2α can trigger increases in ERK1/2 …
cells through common signaling mechanism (s), whereas other related cytokines such as
interleukin-6 and ciliary neurotrophic factor do not cause this response. Induction of DNA
replication by LIF or prostaglandin F 2α (PGF 2α) occurs, in part, through different signaling
events. LIF and OSM specifically trigger STAT1 cytoplasmic to nuclear translocation,
whereas PGF 2α fails to do so. However, LIF and PGF 2α can trigger increases in ERK1/2 …