[HTML][HTML] Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3) …
The ubiquitin-proteasome system facilitates the degradation of ubiquitin-tagged proteins and
performs a regulatory role in cells. Elevated proteasome activity and subunit expression are
found in several cancers. However, the inherent molecular mechanisms responsible for
increased proteasome function in cancers remain unclear despite the well investigated and
defined role of the mammalian proteasome. This study was initiated to elucidate the
mechanisms involved in the regulation of β subunits of the mammalian proteasome …
performs a regulatory role in cells. Elevated proteasome activity and subunit expression are
found in several cancers. However, the inherent molecular mechanisms responsible for
increased proteasome function in cancers remain unclear despite the well investigated and
defined role of the mammalian proteasome. This study was initiated to elucidate the
mechanisms involved in the regulation of β subunits of the mammalian proteasome …