Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)
Interleukin (IL)-32 has been recognized as a proinflammatory cytokine that participates in
responses to viral infection. However, little is known about how IL-32 is induced in response
to viral infection and the mechanisms of IL-32-mediated antiviral activities. We discovered
that IL-32 is elevated by hepatitis B virus (HBV) infection both in vitro and in vivo and that
HBV induced IL-32 expression at the level of both transcription and post-transcription.
Furthermore, microRNA-29b was found to be a key factor in HBV-regulated IL-32 expression …
responses to viral infection. However, little is known about how IL-32 is induced in response
to viral infection and the mechanisms of IL-32-mediated antiviral activities. We discovered
that IL-32 is elevated by hepatitis B virus (HBV) infection both in vitro and in vivo and that
HBV induced IL-32 expression at the level of both transcription and post-transcription.
Furthermore, microRNA-29b was found to be a key factor in HBV-regulated IL-32 expression …
