[HTML][HTML] Kindlin-1 and-2 directly bind the C-terminal region of β integrin cytoplasmic tails and exert integrin-specific activation effects
DS Harburger, M Bouaouina… - Journal of biological …, 2009 - ASBMB
Integrin activation, the rapid conversion of integrin adhesion receptors from low to high
affinity, occurs in response to intracellular signals that act on the short cytoplasmic tails of
integrin β subunits. Talin binding to integrin β tails provides one key activation signal, but
additional factors are likely to cooperate with talin to regulate integrin activation. The integrin
β tail-binding proteins kindlin-2 and kindlin-3 were recently identified as integrin co-
activators. Here we report an analysis of kindlin-1 and kindlin-2 interactions with β1 and β3 …
affinity, occurs in response to intracellular signals that act on the short cytoplasmic tails of
integrin β subunits. Talin binding to integrin β tails provides one key activation signal, but
additional factors are likely to cooperate with talin to regulate integrin activation. The integrin
β tail-binding proteins kindlin-2 and kindlin-3 were recently identified as integrin co-
activators. Here we report an analysis of kindlin-1 and kindlin-2 interactions with β1 and β3 …