Integrin signaling in vascular function
NL Malinin, E Pluskota, TV Byzova - Current opinion in …, 2012 - journals.lww.com
NL Malinin, E Pluskota, TV Byzova
Current opinion in hematology, 2012•journals.lww.comThe role of integrins in angiogenesis has been demonstrated to include, in addition to cell
adhesion and mechanotransduction, specific signaling functions. The importance of integrin
inside-out pathway in vascular physiology has been unequivocally proven, and endothelial
permeability is directly regulated by this process. Inhibition of kindlin-dependent steps in the
inside-out pathway as an approach to block platelet aggregation should be paralog-specific,
as it may have adverse effects on vascular permeability.
adhesion and mechanotransduction, specific signaling functions. The importance of integrin
inside-out pathway in vascular physiology has been unequivocally proven, and endothelial
permeability is directly regulated by this process. Inhibition of kindlin-dependent steps in the
inside-out pathway as an approach to block platelet aggregation should be paralog-specific,
as it may have adverse effects on vascular permeability.
Summary
The role of integrins in angiogenesis has been demonstrated to include, in addition to cell adhesion and mechanotransduction, specific signaling functions. The importance of integrin inside-out pathway in vascular physiology has been unequivocally proven, and endothelial permeability is directly regulated by this process. Inhibition of kindlin-dependent steps in the inside-out pathway as an approach to block platelet aggregation should be paralog-specific, as it may have adverse effects on vascular permeability.
Lippincott Williams & Wilkins