[HTML][HTML] Regulatory B cell-dependent islet transplant tolerance is also natural killer cell dependent
C Schuetz, KM Lee, R Scott, L Kojima… - American Journal of …, 2017 - Elsevier
Immunologic tolerance to solid organ and islet cell grafts has been achieved in various
rodent models by using antibodies directed at CD45RB and Tim-1. We have shown that this
form of tolerance depends on regulatory B cells (Bregs). To elucidate further the mechanism
by which Bregs induce tolerance, we investigated the requirement of natural killer (NK) and
NKT cells in this model. To do so, hyperglycemic B6, μMT, Beige, or CD1d−/− mice received
BALB/c islet grafts and treatment with the tolerance-inducing regimen consisting of anti …
rodent models by using antibodies directed at CD45RB and Tim-1. We have shown that this
form of tolerance depends on regulatory B cells (Bregs). To elucidate further the mechanism
by which Bregs induce tolerance, we investigated the requirement of natural killer (NK) and
NKT cells in this model. To do so, hyperglycemic B6, μMT, Beige, or CD1d−/− mice received
BALB/c islet grafts and treatment with the tolerance-inducing regimen consisting of anti …