[HTML][HTML] Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study [S]
RD Clugston, H Jiang, MX Lee, R Piantedosi… - Journal of lipid …, 2011 - ASBMB
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of
this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed
C57BL/6 mice using a targeted lipidomic approach. Liquid chromatography tandem mass
spectrometry was used to analyze several lipid classes, including free fatty acids, fatty acyl-
CoAs, fatty acid ethyl esters, sphingolipids, ceramides, and endocannabinoids, in plasma
and liver samples from control and alcohol-fed mice. The interpretation of lipidomic data was …
this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed
C57BL/6 mice using a targeted lipidomic approach. Liquid chromatography tandem mass
spectrometry was used to analyze several lipid classes, including free fatty acids, fatty acyl-
CoAs, fatty acid ethyl esters, sphingolipids, ceramides, and endocannabinoids, in plasma
and liver samples from control and alcohol-fed mice. The interpretation of lipidomic data was …