Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and …
MJ Dekker, C Baker, M Naples, J Samsoondar… - Atherosclerosis, 2013 - Elsevier
Sphingolipids have emerged as important bioactive lipid species involved in the
pathogenesis of type 2 diabetes and cardiovascular disease. However, little is known of the
regulatory role of sphingolipids in dyslipidemia of insulin-resistant states. We employed
hamster models of dyslipidemia and insulin resistance to investigate the role of
sphingolipids in hepatic VLDL overproduction, induction of insulin resistance, and
inflammation. Hamsters were fed either a control chow diet, a high fructose diet, or a diet …
pathogenesis of type 2 diabetes and cardiovascular disease. However, little is known of the
regulatory role of sphingolipids in dyslipidemia of insulin-resistant states. We employed
hamster models of dyslipidemia and insulin resistance to investigate the role of
sphingolipids in hepatic VLDL overproduction, induction of insulin resistance, and
inflammation. Hamsters were fed either a control chow diet, a high fructose diet, or a diet …