Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular …
H Tuunanen, E Engblom, A Naum, M Scheinin… - Journal of cardiac …, 2006 - Elsevier
BACKGROUND: Results on myocardial substrate metabolism in the failing heart have been
contradictory. Insulin resistance, a common comorbidity in heart failure patients, and medical
therapy may modify myocardial metabolism in complex fashions. Therefore, we
characterized myocardial oxidative and free fatty acid (FFA) metabolism in patients with
idiopathic dilated cardiomyopathy (IDCM) and investigated the contributions of insulin
resistance and β-blocker therapy. METHODS AND RESULTS: Nineteen patients with IDCM …
contradictory. Insulin resistance, a common comorbidity in heart failure patients, and medical
therapy may modify myocardial metabolism in complex fashions. Therefore, we
characterized myocardial oxidative and free fatty acid (FFA) metabolism in patients with
idiopathic dilated cardiomyopathy (IDCM) and investigated the contributions of insulin
resistance and β-blocker therapy. METHODS AND RESULTS: Nineteen patients with IDCM …