Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
R Morikawa, N Nakamoto, T Amiya, P Chu, Y Koda… - Journal of …, 2021 - Elsevier
Background & Aims The number of patients with non-alcoholic steatohepatitis (NASH) is
increasing globally. Recently, specific chemokine receptors have garnered interest as
therapeutic targets in NASH. This is the first report to examine the role of the CC chemokine
receptor 9 (CCR9)/CC chemokine receptor ligand 25 (CCL25) axis, and to reveal its
therapeutic potential in NASH. Methods Patients with biopsy-proven non-alcoholic liver
disease (NAFLD) were recruited and their serum and hepatic chemokine expression was …
increasing globally. Recently, specific chemokine receptors have garnered interest as
therapeutic targets in NASH. This is the first report to examine the role of the CC chemokine
receptor 9 (CCR9)/CC chemokine receptor ligand 25 (CCL25) axis, and to reveal its
therapeutic potential in NASH. Methods Patients with biopsy-proven non-alcoholic liver
disease (NAFLD) were recruited and their serum and hepatic chemokine expression was …
