Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells
D Tokita, TL Sumpter, G Raimondi, AF Zahorchak… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: The liver is comparatively rich in plasmacytoid (p) dendritic cells
(DC),–innate immune effector cells that are also thought to play key roles in the induction
and regulation of adaptive immunity. METHODS: Liver and spleen pDC were purified from
fms-like tyrosine kinase ligand-treated control or lipopolysaccharide-injected C57BL/10
mice. Flow cytometric and molecular biologic assays were used to characterize their function
and interaction with naturally occurring regulatory T cells (Treg). RESULTS: While IL-10 …
(DC),–innate immune effector cells that are also thought to play key roles in the induction
and regulation of adaptive immunity. METHODS: Liver and spleen pDC were purified from
fms-like tyrosine kinase ligand-treated control or lipopolysaccharide-injected C57BL/10
mice. Flow cytometric and molecular biologic assays were used to characterize their function
and interaction with naturally occurring regulatory T cells (Treg). RESULTS: While IL-10 …