Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo …
SB Andugulapati, K Gourishetti, SK Tirunavalli… - Phytomedicine, 2020 - Elsevier
Abstract Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive inflammatory
disorder driven by a fibrotic cascade of events such as epithelial to mesenchymal transition,
extracellular matrix production and collagen formation in the lungs in a sequential manner.
IPF incidences were raising rapidly across the world. FDA approved pirfenidone and
nintedanib (tyrosine kinase inhibitors) are being used as a first-line treatment drugs for IPF,
however, neither the quality of life nor survival rates have been improved because of patient …
disorder driven by a fibrotic cascade of events such as epithelial to mesenchymal transition,
extracellular matrix production and collagen formation in the lungs in a sequential manner.
IPF incidences were raising rapidly across the world. FDA approved pirfenidone and
nintedanib (tyrosine kinase inhibitors) are being used as a first-line treatment drugs for IPF,
however, neither the quality of life nor survival rates have been improved because of patient …