[HTML][HTML] Myeloperoxidase, modified lipoproteins, and atherogenesis

SJ Nicholls, SL Hazen - Journal of lipid research, 2009 - ASBMB
Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis
of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source
of eicosanoids and bioactive lipids and generates atherogenic forms of both low-and high-
density lipoproteins. These factors likely contribute to clinical studies demonstrating that
increased systemic levels of MPO and its oxidation products predict increased
cardiovascular risk. As a result, interest has focused on the potential to target MPO for the …