Antihistone and anti–double-stranded deoxyribonucleic acid antibodies are associated with renal disease in systemic lupus erythematosus
J Cortés-Hernández, J Ordi-Ros, M Labrador… - The American journal of …, 2004 - Elsevier
PURPOSE: We sought to assess the nephritogenic antibody profile of patients with systemic
lupus erythematosus (SLE), and to determine which antibodies were most useful in
identifying patients at risk of nephritis. METHODS: We studied 199 patients with SLE, 78 of
whom had lupus nephritis. We assayed serum samples for antibodies against chromatin
components (double-stranded deoxyribonucleic acid [dsDNA], nucleosome, and histone),
C1q, basement membrane components (laminin, fibronectin, and type IV collagen) …
lupus erythematosus (SLE), and to determine which antibodies were most useful in
identifying patients at risk of nephritis. METHODS: We studied 199 patients with SLE, 78 of
whom had lupus nephritis. We assayed serum samples for antibodies against chromatin
components (double-stranded deoxyribonucleic acid [dsDNA], nucleosome, and histone),
C1q, basement membrane components (laminin, fibronectin, and type IV collagen) …