The role of complement in the development of systemic lupus erythematosus
AP Manderson, M Botto, MJ Walport - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract Complement has both beneficial and deleterious roles in the pathogenesis of
systemic lupus erythematosus (SLE). On the one hand, patients with SLE present with
decreased complement levels and with complement deposition in inflammed tissues,
suggestive of a harmful role of complement in the effector phase of disease. On the other
hand, homozygous deficiency of any of the classical pathway proteins is strongly associated
with the development of SLE. There are two main hypotheses to explain these observations …
systemic lupus erythematosus (SLE). On the one hand, patients with SLE present with
decreased complement levels and with complement deposition in inflammed tissues,
suggestive of a harmful role of complement in the effector phase of disease. On the other
hand, homozygous deficiency of any of the classical pathway proteins is strongly associated
with the development of SLE. There are two main hypotheses to explain these observations …