A female preponderance for chemically induced lupus in SJL/J mice
DL Smith, X Dong, S Du, MS Oh, RR Singh… - Clinical …, 2007 - Elsevier
Both spontaneous and chemically induced rodent models of autoimmune nephritis and
autoantibody production have been explored to understand mechanisms involved in human
systemic lupus erythematosus (SLE). While it has been known for decades that women are
more susceptible than men to SLE, mechanisms underlying this female preponderance
remain unclear. One chemically induced model involves injection of hydrocarbon oils such
as pristane into otherwise normal mouse strains, which results in the development of …
autoantibody production have been explored to understand mechanisms involved in human
systemic lupus erythematosus (SLE). While it has been known for decades that women are
more susceptible than men to SLE, mechanisms underlying this female preponderance
remain unclear. One chemically induced model involves injection of hydrocarbon oils such
as pristane into otherwise normal mouse strains, which results in the development of …