Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome
Background Multisystem inflammatory syndrome in children (MIS-C) is an acute, febrile,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated syndrome,
often with cardiohemodynamic dysfunction. Insight into mechanism of disease is still
incomplete. Objective Our objective was to analyze immunologic features of MIS-C patients
compared to febrile controls (FC). Methods MIS-C patients were defined by narrow criteria,
including having evidence of cardiohemodynamic involvement and no macrophage …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated syndrome,
often with cardiohemodynamic dysfunction. Insight into mechanism of disease is still
incomplete. Objective Our objective was to analyze immunologic features of MIS-C patients
compared to febrile controls (FC). Methods MIS-C patients were defined by narrow criteria,
including having evidence of cardiohemodynamic involvement and no macrophage …