Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein
H Du, DP Witte, GA Grabowski - Journal of lipid research, 1996 - ASBMB
Lysosomal acid lipase (LAL) is essential to the intracellular control of cholesterol and
triglyceride catabolism via the low density lipoprotein (LDL) delivery of these neutral lipids to
the lysosome. Deficiency of LAL in humans leads to Wolman disease and cholesteryl ester
storage disease that result, respectively, in the intralysosomal storage of both neutral lipids
or only cholesteryl esters. The mouse and human LAL cDNAs were cloned. The deduced
amino acid sequences from the mouse and human LAL had high similarity (95%) and …
triglyceride catabolism via the low density lipoprotein (LDL) delivery of these neutral lipids to
the lysosome. Deficiency of LAL in humans leads to Wolman disease and cholesteryl ester
storage disease that result, respectively, in the intralysosomal storage of both neutral lipids
or only cholesteryl esters. The mouse and human LAL cDNAs were cloned. The deduced
amino acid sequences from the mouse and human LAL had high similarity (95%) and …