Expression of ceramide synthase 6 transcriptionally activates acid ceramidase in a c-Jun N-terminal kinase (JNK)-dependent manner
TS Tirodkar, P Lu, A Bai, MJ Scheffel, S Gencer… - Journal of Biological …, 2015 - jbc.org
A family of six ceramide synthases with distinct but overlapping substrate specificities is
responsible for generation of ceramides with acyl chains ranging from∼ 14–26 carbons.
Ceramide synthase 6 (CerS6) preferentially generates C 14-and C 16-ceramides, and we
have previously shown that down-regulation of this enzyme decreases apoptotic
susceptibility. In this study, we further evaluated how increased CerS6 expression impacts
sphingolipid composition and metabolism. Overexpression of CerS6 in HT29 colon cancer …
responsible for generation of ceramides with acyl chains ranging from∼ 14–26 carbons.
Ceramide synthase 6 (CerS6) preferentially generates C 14-and C 16-ceramides, and we
have previously shown that down-regulation of this enzyme decreases apoptotic
susceptibility. In this study, we further evaluated how increased CerS6 expression impacts
sphingolipid composition and metabolism. Overexpression of CerS6 in HT29 colon cancer …
