[HTML][HTML] A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy
Y Pewzner-Jung, O Brenner, S Braun, EL Laviad… - Journal of Biological …, 2010 - ASBMB
We have generated a mouse that cannot synthesize very long acyl chain (C22–C24)
ceramides (Pewzner-Jung, Y., Park, H., Laviad, EL, Silva, LC, Lahiri, S., Stiban, J., Erez-
Roman, R., Brugger, B., Sachsenheimer, T., Wieland, FT, Prieto, M., Merrill, AH, and
Futerman, AH (2010) J. Biol. Chem. 285, 10902–10910) due to ablation of ceramide
synthase 2 (CerS2). As a result, significant changes were observed in the sphingolipid
profile of livers from these mice, including elevated C16-ceramide and sphinganine levels …
ceramides (Pewzner-Jung, Y., Park, H., Laviad, EL, Silva, LC, Lahiri, S., Stiban, J., Erez-
Roman, R., Brugger, B., Sachsenheimer, T., Wieland, FT, Prieto, M., Merrill, AH, and
Futerman, AH (2010) J. Biol. Chem. 285, 10902–10910) due to ablation of ceramide
synthase 2 (CerS2). As a result, significant changes were observed in the sphingolipid
profile of livers from these mice, including elevated C16-ceramide and sphinganine levels …