Inhibitors of specific ceramide synthases
S Schiffmann, D Hartmann, S Fuchs, K Birod… - Biochimie, 2012 - Elsevier
Ceramide synthases (CerSs) are key enzymes in the biosynthesis of ceramides and display
a group of at least six different isoenzymes (CerS1-6). Ceramides itself are bioactive
molecules. Ceramides with different N-acyl side chains (C14: 0-Cer–C26: 0-Cer) possess
distinct roles in cell signaling. Therefore, the selective inhibition of specific CerSs which are
responsible for the formation of a specific ceramide holds promise for a number of new
clinical treatment strategies, eg, cancer. Here, we identified four of hitherto unknown …
a group of at least six different isoenzymes (CerS1-6). Ceramides itself are bioactive
molecules. Ceramides with different N-acyl side chains (C14: 0-Cer–C26: 0-Cer) possess
distinct roles in cell signaling. Therefore, the selective inhibition of specific CerSs which are
responsible for the formation of a specific ceramide holds promise for a number of new
clinical treatment strategies, eg, cancer. Here, we identified four of hitherto unknown …
