Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity
S Deaglio, SC Robson - Advances in pharmacology, 2011 - Elsevier
Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular
injury and thrombophilia, inflammation, and immune disturbance. Within the vasculature,
spatial and temporal expression of CD39 nucleoside triphosphate diphosphohydrolase
(NTPDase) family members together with CD73 ecto-5′-nucleotidase control platelet
activation, thrombus size, and stability. This is achieved by closely regulated …
among others, have implicated purinergic signaling in clinical manifestations of vascular
injury and thrombophilia, inflammation, and immune disturbance. Within the vasculature,
spatial and temporal expression of CD39 nucleoside triphosphate diphosphohydrolase
(NTPDase) family members together with CD73 ecto-5′-nucleotidase control platelet
activation, thrombus size, and stability. This is achieved by closely regulated …