Ubiquinone Is Necessary for Caenorhabditis elegansDevelopment at Mitochondrial and Non-mitochondrial Sites
AK Hihi, Y Gao, S Hekimi - Journal of Biological Chemistry, 2002 - ASBMB
Ubiquinone (UQ) is a lipid co-factor that is involved in numerous enzymatic processes and is
present in most cellular membranes. In particular, UQ is a crucial electron carrier in the
mitochondrial respiratory chain. Recently, it was shown thatclk-1 mutants of the nematode
worm Caenorhabditis elegans do not synthesize UQ 9 but instead accumulate
demethoxyubiquinone (DMQ 9), a biosynthetic precursor of UQ 9 (the subscript refers to the
length of the isoprenoid side chain). DMQ 9 is capable of carrying out the function of UQ 9 in …
present in most cellular membranes. In particular, UQ is a crucial electron carrier in the
mitochondrial respiratory chain. Recently, it was shown thatclk-1 mutants of the nematode
worm Caenorhabditis elegans do not synthesize UQ 9 but instead accumulate
demethoxyubiquinone (DMQ 9), a biosynthetic precursor of UQ 9 (the subscript refers to the
length of the isoprenoid side chain). DMQ 9 is capable of carrying out the function of UQ 9 in …
