[HTML][HTML] Mitochondrial respiratory chain deficiency inCaenorhabditis elegans results in developmental arrest and increased life span
WY Tsang, LC Sayles, LI Grad, DB Pilgrim… - Journal of Biological …, 2001 - ASBMB
The growth and development ofCaenorhabditis elegans are energy-dependent and rely on
the mitochondrial respiratory chain (MRC) as the major source of ATP. The MRC is
composed of∼ 70 nuclear and 12 mitochondrial gene products. Complexes I and V are
multisubunit proteins of the MRC. Thenuo-1 gene encodes the NADH-and FMN-binding
subunit of complex I, the NADH-ubiquinone oxidoreductase. The atp-2gene encodes the
active-site subunit of complex V, the ATP synthase. The nuo-1 (ua1) and atp-2 (ua2) …
the mitochondrial respiratory chain (MRC) as the major source of ATP. The MRC is
composed of∼ 70 nuclear and 12 mitochondrial gene products. Complexes I and V are
multisubunit proteins of the MRC. Thenuo-1 gene encodes the NADH-and FMN-binding
subunit of complex I, the NADH-ubiquinone oxidoreductase. The atp-2gene encodes the
active-site subunit of complex V, the ATP synthase. The nuo-1 (ua1) and atp-2 (ua2) …