N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease
E Polyak, J Ostrovsky, M Peng, SD Dingley… - Molecular Genetics and …, 2018 - Elsevier
Oxidative stress is a known contributing factor in mitochondrial respiratory chain (RC)
disease pathogenesis. Yet, no efficient means exists to objectively evaluate the comparative
therapeutic efficacy or toxicity of different antioxidant compounds empirically used in human
RC disease. We postulated that pre-clinical comparative analysis of diverse antioxidant
drugs having suggested utility in primary RC disease using animal and cellular models of
RC dysfunction may improve understanding of their integrated effects and physiologic …
disease pathogenesis. Yet, no efficient means exists to objectively evaluate the comparative
therapeutic efficacy or toxicity of different antioxidant compounds empirically used in human
RC disease. We postulated that pre-clinical comparative analysis of diverse antioxidant
drugs having suggested utility in primary RC disease using animal and cellular models of
RC dysfunction may improve understanding of their integrated effects and physiologic …